Rapid discovery of gene function

Healthy Lives


09:00 - 09:45

Working with mice, and pairing new computational methods with high speed sequencing, we now determine the causes of phenotypes in real time.  When a phenotype induced by a germline mutagen is detected, its mutational cause is instantly known as well.  Approximately one third of the mouse genome has so far been damaged or destroyed under close phenotypic surveillance.  Many new proteins, not previously known to participate in immunity, have been identified in this way.  Moreover, it is possible to use the same system to identify mutations that eliminate disease.  Disease modifier loci can, in some cases, be attractive targets for drug development.

Bruce Beuteler 2

Bruce Beutler

Bruce Beutler studied medicine at the University of Chicago. Early in his career h...