Garry Nolan is the Rachford and Carlota A. Harris Professor
in the Department of Microbiology and Immunology at Stanford University School
of Medicine. He trained with Leonard Herzenberg (for his Ph.D.) and Nobelist
Dr. David Baltimore (for postdoctoral work for the first cloning/characterization
of NF-B p65/ RelA and the development of rapid retroviral production systems).
He has published over 220 research articles and is the holder of 20 US patents,
and has been honored as one of the top 25 inventors at Stanford University.
Dr. Nolan is the first recipient of the Teal Innovator Award (2012) from the
Department of Defense (a $3.3 million grant for advanced studies in ovarian
cancer), the first recipient of an FDA BAAA, for "Bio-agent
protection" grant, $3million, from the FDA for a "Cross-Species
Immune System Reference", and received the award for "Outstanding
Research Achievement in 2011" from the Nature Publishing Group for his
development of CyTOF applications in the immune system. Dr. Nolan has new
efforts in the study of Ebola, having developed instrument platforms to deploy
in the field in Africa to study Ebola samples safely with the need to transport
them to overseas labs (funded by a new $3.5 million grant from the FDA).
Dr. Nolan is an outspoken proponent of translating public investment in basic
research to serve public welfare. Dr. Nolan was the founder of Rigel Inc.
(NASDAQ: RIGL, BINA (a genomics computational infrastructure company sold to
Roche Diagnostics), and serves on the Boards of Directors of several companies
as well as consults for other biotechnology companies. DVS Sciences, on which
he was Chair of the Scientific Advisory Board, sold to Fluidigm for $207
million dollars (2014) on an investment of $14 million.
His areas of research include hematopoiesis, cancer and leukemia, autoimmunity
and inflammation, and computational approaches for network and systems
immunology. Dr. Nolan's recent efforts are focused on a single cell analysis
advance using a mass spectrometry-flow cytometry hybrid device (CyTOF) and
nanoscale imaging with the "Multiparameter Ion Beam Imager" (MIBI).
The approaches use an advanced ion plasma source to determine the levels of
tagged reagents bound to cells - enabling a vast increase in the number of
parameters that can be measured per cell - either as flow cytometry devices
(CyTOF) or imaging platforms for cancer (MIBI). Further developments in imaging
are enabled by CODEX—a system that inexpensively converts fluorescence scopes
into high dimensional imaging platforms.
Dr. Nolan's efforts are to enable a deeper understanding not only of normal
immune function, trauma, pathogen infection, and other inflammatory events but
also detailed substructures of leukemias and solid cancers to enable new
understandings that will enable better management of disease and clinical outcomes.